TYPPEX

Tailoring evidence-based psychological therapY for People with common mental disorders including Psychotic EXperiences.

What is TYPPEX?

The NIHR TYPPEX programme focuses on a hitherto unidentified group of patients receiving NHS talking therapies for depression and anxiety. Theoretically predicted and endorsed by our lived-experience advisory panel, researchers discovered that almost a third of patients are experiencing psychotic phenomena (such as hallucinations and inexplicable suspiciousness) that marks more severe depression and anxiety, and predicts poor outcomes in services that, nationally, treat more than a million people a year. With strong input from people with lived experience (coordinated by the McPin Foundation), the programme then tailored a new blend of existing psychological therapies to address this presentation that previously hid in plain sight, and are in the final stages of a multi-centre, stepped-wedge RCT. This is a disruptive, trans-diagnostic programme that may not only have important therapeutic impacts, but will lead to a reappraisal of psychotic experiences in clinical settings where they were once assumed to be harbingers of other mental disorders such as schizophrenia. The trial is due to report in January 2025.

We Want to Make the Difference.

For people experiencing a common mental health disorder as well as psychotic experiences, neither NHS Talking services nor early intervention services fully meet their needs. One of our service-user advisors said:

“It was like being stranded in no-man’s-land…there was simply no service that was right for me”.

The TYPPEX study will develop and evaluate a form of talking therapy that will meet the needs of people with a common mental health condition and psychotic experiences.

" 48%* of the people receiving treatment in NHS Talking Therapies have psychotic experiences."

 

*This percentage (48%) was calculated using a more sensitive threshold for the CAPE questionnaire to measure the prevalence of psychotic experiences and their impact on recovery within the TYPPEX programme. When using a more specific threshold, the percentage was 30%. You can read about the rational and findings associated with both cut-offs here and here.  

Exciting News: New Research Paper Published

We are thrilled to announce the publication of our latest paper describing the types of PEs experienced in an IAPT  (now known as NHS Talking Therapies) setting. The paper, titledClinical presentation of psychotic experiences in patients with common mental disorders attending the UK primary care improving access to psychological therapies (IAPT) Programme” is now available for review here.

How it Started...

Read more about how it all started in 2008. From our trailblazing former study, systemic review on psychological interventions for people with psychotic experiences, to our feasibility study and respective process evaluation and finally, the beginning of the RCT.

To our Collaborators

The TYPPEX team gratefully acknowledge the generous support from our sponsors and collaborators.

“We want services to help people with the problems they have, not the illnesses they may, but probably won’t develop. We aim to develop precision psychotherapy for people with a particular combination of problems that just hasn’t been properly recognised in the past.”

Prof. Peter Jones

Co-Chief Investigator, University of Cambridge

There are a range of treatments available for psychotic experiences, but no clear pathway to bring them into services where most people are already seeking help for other conditions. One patient described to me that they felt there was no right service to meet all their needs- they felt they were in no-man’s land.”

Prof. Jesus Perez

Co-Chief Investigator, University of Cambridge

From The Blog

Read more about our dissemination events and the backstage while working in clinical research. 

Read Our Newsletters

May 2024

Trial update sent to our therapits and collaborators. Read it here and here!

December 2023

Trial update sent to our therapits and collaborators. Read it here and here!

October 2023

Trial update sent to our therapits. Read it here!

September 2023

Trial update sent to our collaborators. Read it here!

May 2023

Trial update sent to our therapists. Read it here!

October 2022

Trial update sent to our collaboratos and therapists. Read it here and here!

December 2019

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August 2019

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